RapamycinFungusV1, Main, Exploration, bibRecord, 000240

Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.

Identifieur interne : 000240 ( Main/Exploration ); précédent : 000239; suivant : 000241

Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.

Auteurs : Ling-Ling Teng [Taïwan] ; Guan-Ling Lu [Taïwan] ; Lih-Chu Chiou [Taïwan] ; Wei-Sheng Lin [Taïwan] ; Ya-Yun Cheng [Taïwan] ; Tai-En Hsueh [Taïwan] ; Yi-Ching Huang [Taïwan] ; Nai-Hsuan Hwang [Taïwan] ; Jin-Wei Yeh [Taïwan] ; Ruey-Ming Liao [Taïwan] ; Shou-Zen Fan [Taïwan] ; Jui-Hung Yen [États-Unis] ; Tsai-Feng Fu [Taïwan] ; Ting-Fen Tsai [Taïwan] ; Ming-Shiang Wu [Taïwan] ; Pei-Yu Wang [Taïwan]

Source :

PLoS biology [ 1545-7885 ] ; 2019.

RBID : pubmed:30883547

Descripteurs français

English descriptors

KwdEn :
- 3-Hydroxybutyric Acid (blood), Animals (MeSH), Blotting, Western (MeSH), Corticosterone (blood), Electrophysiology (MeSH), Glucose Tolerance Test (MeSH), Hippocampus (cytology), Hippocampus (metabolism), Long-Term Potentiation (physiology), Male (MeSH), Mechanistic Target of Rapamycin Complex 1 (genetics), Mechanistic Target of Rapamycin Complex 1 (metabolism), Memory (physiology), Mice (MeSH), Mice, Inbred C57BL (MeSH), Neurons (cytology), Neurons (metabolism), RNA, Messenger (metabolism), Receptors, Serotonin (genetics), Receptors, Serotonin (metabolism), Serotonin (blood), Signal Transduction (genetics), Signal Transduction (physiology).
MESH :
- chemical , blood : 3-Hydroxybutyric Acid, Corticosterone, Serotonin.
- cytology : Hippocampus, Neurons.
- chemical , genetics : Mechanistic Target of Rapamycin Complex 1, Receptors, Serotonin, Signal Transduction.
- metabolism : Hippocampus, Mechanistic Target of Rapamycin Complex 1, Neurons, RNA, Messenger, Receptors, Serotonin.
- physiology : Long-Term Potentiation, Memory, Signal Transduction.
- Animals, Blotting, Western, Electrophysiology, Glucose Tolerance Test, Male, Mice, Mice, Inbred C57BL.

Abstract

Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on physiological, psychological, and behavioral outcomes in animals and in humans. We have explored the molecular mechanism of DR-induced memory enhancement and demonstrate that dietary tryptophan-a precursor amino acid for serotonin biosynthesis in the brain-and serotonin receptor 5-hydroxytryptamine receptor 6 (HTR6) are crucial in mediating this process. We show that HTR6 inactivation diminishes DR-induced neurological alterations, including reduced dendritic complexity, increased spine density, and enhanced long-term potentiation (LTP) in hippocampal neurons. Moreover, we find that HTR6-mediated mechanistic target of rapamycin complex 1 (mTORC1) signaling is involved in DR-induced memory improvement. Our results suggest that the HTR6-mediated mTORC1 pathway may function as a nutrient sensor in hippocampal neurons to couple memory performance to dietary intake.

DOI: 10.1371/journal.pbio.2007097
PubMed: 30883547
PubMed Central: PMC6438579

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000320
to stream Main, to step Curation: 000320

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.</title>
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<country xml:lang="fr">Taïwan</country>
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<author><name sortKey="Fan, Shou Zen" sort="Fan, Shou Zen" uniqKey="Fan S" first="Shou-Zen" last="Fan">Shou-Zen Fan</name>
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<author><name sortKey="Yen, Jui Hung" sort="Yen, Jui Hung" uniqKey="Yen J" first="Jui-Hung" last="Yen">Jui-Hung Yen</name>
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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Applied Chemistry, National Chi Nan University, Nantou</wicri:regionArea>
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<author><name sortKey="Tsai, Ting Fen" sort="Tsai, Ting Fen" uniqKey="Tsai T" first="Ting-Fen" last="Tsai">Ting-Fen Tsai</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Wu, Ming Shiang" sort="Wu, Ming Shiang" uniqKey="Wu M" first="Ming-Shiang" last="Wu">Ming-Shiang Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Wang, Pei Yu" sort="Wang, Pei Yu" uniqKey="Wang P" first="Pei-Yu" last="Wang">Pei-Yu Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan.</nlm:affiliation>
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<affiliation wicri:level="1"><nlm:affiliation>Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan.</nlm:affiliation>
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<affiliation wicri:level="1"><nlm:affiliation>Center for Systems Biology, National Taiwan University, Taipei, Taiwan.</nlm:affiliation>
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<wicri:noRegion>Taipei</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:affiliation>PhD Program in Translational Medicine, National Taiwan University and Academia Sinica, Taipei, Taiwan.</nlm:affiliation>
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</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei</wicri:regionArea>
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<series><title level="j">PLoS biology</title>
<idno type="eISSN">1545-7885</idno>
<imprint><date when="2019" type="published">2019</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>3-Hydroxybutyric Acid (blood)</term>
<term>Animals (MeSH)</term>
<term>Blotting, Western (MeSH)</term>
<term>Corticosterone (blood)</term>
<term>Electrophysiology (MeSH)</term>
<term>Glucose Tolerance Test (MeSH)</term>
<term>Hippocampus (cytology)</term>
<term>Hippocampus (metabolism)</term>
<term>Long-Term Potentiation (physiology)</term>
<term>Male (MeSH)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (genetics)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (metabolism)</term>
<term>Memory (physiology)</term>
<term>Mice (MeSH)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Neurons (cytology)</term>
<term>Neurons (metabolism)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Receptors, Serotonin (genetics)</term>
<term>Receptors, Serotonin (metabolism)</term>
<term>Serotonin (blood)</term>
<term>Signal Transduction (genetics)</term>
<term>Signal Transduction (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (métabolisme)</term>
<term>Acide 3-hydroxy-butyrique (sang)</term>
<term>Animaux (MeSH)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (génétique)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (métabolisme)</term>
<term>Corticostérone (sang)</term>
<term>Hippocampe (cytologie)</term>
<term>Hippocampe (métabolisme)</term>
<term>Hyperglycémie provoquée (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Mémoire (physiologie)</term>
<term>Neurones (cytologie)</term>
<term>Neurones (métabolisme)</term>
<term>Potentialisation à long terme (physiologie)</term>
<term>Récepteurs sérotoninergiques (génétique)</term>
<term>Récepteurs sérotoninergiques (métabolisme)</term>
<term>Souris (MeSH)</term>
<term>Souris de lignée C57BL (MeSH)</term>
<term>Sérotonine (sang)</term>
<term>Technique de Western (MeSH)</term>
<term>Transduction du signal (génétique)</term>
<term>Transduction du signal (physiologie)</term>
<term>Électrophysiologie (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>3-Hydroxybutyric Acid</term>
<term>Corticosterone</term>
<term>Serotonin</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Hippocampe</term>
<term>Neurones</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Hippocampus</term>
<term>Neurons</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Mechanistic Target of Rapamycin Complex 1</term>
<term>Receptors, Serotonin</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Récepteurs sérotoninergiques</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hippocampus</term>
<term>Mechanistic Target of Rapamycin Complex 1</term>
<term>Neurons</term>
<term>RNA, Messenger</term>
<term>Receptors, Serotonin</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term>
<term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Hippocampe</term>
<term>Neurones</term>
<term>Récepteurs sérotoninergiques</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Mémoire</term>
<term>Potentialisation à long terme</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Long-Term Potentiation</term>
<term>Memory</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Acide 3-hydroxy-butyrique</term>
<term>Corticostérone</term>
<term>Sérotonine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Blotting, Western</term>
<term>Electrophysiology</term>
<term>Glucose Tolerance Test</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Hyperglycémie provoquée</term>
<term>Mâle</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Technique de Western</term>
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<front><div type="abstract" xml:lang="en">Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on physiological, psychological, and behavioral outcomes in animals and in humans. We have explored the molecular mechanism of DR-induced memory enhancement and demonstrate that dietary tryptophan-a precursor amino acid for serotonin biosynthesis in the brain-and serotonin receptor 5-hydroxytryptamine receptor 6 (HTR6) are crucial in mediating this process. We show that HTR6 inactivation diminishes DR-induced neurological alterations, including reduced dendritic complexity, increased spine density, and enhanced long-term potentiation (LTP) in hippocampal neurons. Moreover, we find that HTR6-mediated mechanistic target of rapamycin complex 1 (mTORC1) signaling is involved in DR-induced memory improvement. Our results suggest that the HTR6-mediated mTORC1 pathway may function as a nutrient sensor in hippocampal neurons to couple memory performance to dietary intake.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30883547</PMID>
<DateCompleted><Year>2019</Year>
<Month>11</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1545-7885</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>17</Volume>
<Issue>3</Issue>
<PubDate><Year>2019</Year>
<Month>03</Month>
</PubDate>
</JournalIssue>
<Title>PLoS biology</Title>
<ISOAbbreviation>PLoS Biol</ISOAbbreviation>
</Journal>
<ArticleTitle>Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.</ArticleTitle>
<Pagination><MedlinePgn>e2007097</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pbio.2007097</ELocationID>
<Abstract><AbstractText>Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on physiological, psychological, and behavioral outcomes in animals and in humans. We have explored the molecular mechanism of DR-induced memory enhancement and demonstrate that dietary tryptophan-a precursor amino acid for serotonin biosynthesis in the brain-and serotonin receptor 5-hydroxytryptamine receptor 6 (HTR6) are crucial in mediating this process. We show that HTR6 inactivation diminishes DR-induced neurological alterations, including reduced dendritic complexity, increased spine density, and enhanced long-term potentiation (LTP) in hippocampal neurons. Moreover, we find that HTR6-mediated mechanistic target of rapamycin complex 1 (mTORC1) signaling is involved in DR-induced memory improvement. Our results suggest that the HTR6-mediated mTORC1 pathway may function as a nutrient sensor in hippocampal neurons to couple memory performance to dietary intake.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Teng</LastName>
<ForeName>Ling-Ling</ForeName>
<Initials>LL</Initials>
<AffiliationInfo><Affiliation>Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Guan-Ling</ForeName>
<Initials>GL</Initials>
<AffiliationInfo><Affiliation>Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chiou</LastName>
<ForeName>Lih-Chu</ForeName>
<Initials>LC</Initials>
<AffiliationInfo><Affiliation>Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Wei-Sheng</ForeName>
<Initials>WS</Initials>
<AffiliationInfo><Affiliation>Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pediatrics, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cheng</LastName>
<ForeName>Ya-Yun</ForeName>
<Initials>YY</Initials>
<AffiliationInfo><Affiliation>Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hsueh</LastName>
<ForeName>Tai-En</ForeName>
<Initials>TE</Initials>
<AffiliationInfo><Affiliation>Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Yi-Ching</ForeName>
<Initials>YC</Initials>
<AffiliationInfo><Affiliation>Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hwang</LastName>
<ForeName>Nai-Hsuan</ForeName>
<Initials>NH</Initials>
<AffiliationInfo><Affiliation>Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Neuroscience, National Cheng-Chi University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yeh</LastName>
<ForeName>Jin-Wei</ForeName>
<Initials>JW</Initials>
<AffiliationInfo><Affiliation>Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liao</LastName>
<ForeName>Ruey-Ming</ForeName>
<Initials>RM</Initials>
<AffiliationInfo><Affiliation>Institute of Neuroscience, National Cheng-Chi University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fan</LastName>
<ForeName>Shou-Zen</ForeName>
<Initials>SZ</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yen</LastName>
<ForeName>Jui-Hung</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Indiana University School of Medicine, Fort Wayne, Indiana, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fu</LastName>
<ForeName>Tsai-Feng</ForeName>
<Initials>TF</Initials>
<AffiliationInfo><Affiliation>Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tsai</LastName>
<ForeName>Ting-Fen</ForeName>
<Initials>TF</Initials>
<AffiliationInfo><Affiliation>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Ming-Shiang</ForeName>
<Initials>MS</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Pei-Yu</ForeName>
<Initials>PY</Initials>
<Identifier Source="ORCID">0000-0002-1792-8935</Identifier>
<AffiliationInfo><Affiliation>Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Systems Biology, National Taiwan University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>PhD Program in Translational Medicine, National Taiwan University and Academia Sinica, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>03</Month>
<Day>18</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS Biol</MedlineTA>
<NlmUniqueID>101183755</NlmUniqueID>
<ISSNLinking>1544-9173</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011985">Receptors, Serotonin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C097216">serotonin 6 receptor</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>333DO1RDJY</RegistryNumber>
<NameOfSubstance UI="D012701">Serotonin</NameOfSubstance>
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<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003345" MajorTopicYN="N">Corticosterone</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004594" MajorTopicYN="N">Electrophysiology</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005951" MajorTopicYN="N">Glucose Tolerance Test</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006624" MajorTopicYN="N">Hippocampus</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
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<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008568" MajorTopicYN="N">Memory</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011985" MajorTopicYN="N">Receptors, Serotonin</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012701" MajorTopicYN="N">Serotonin</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<CoiStatement>The authors have declared that no competing interests exist.</CoiStatement>
</MedlineCitation>
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<Day>08</Day>
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   |texte=   Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.
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	Serveur d'exploration sur la rapamycine et les champignons
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Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.

Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.

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